In the field of purinergic signaling, the P2Y12 protein on the periphery is found mainly but not exclusively on the surface of blood platelets, and is an important regulator in blood clotting. [9]

To determine the degree of platelet inhibition from the use of P2Y12 inhibition drug therapies known as thienopyridines. These include Clopidogrel (Plavix), Prasugrel, Ticlopidine (Ticlid), and Ticagrelor.

Jul 14, 2024 · Antiplatelet medicines work to make your platelets less sticky and thereby help prevent blood clots from forming in your arteries. Aspirin is an antiplatelet medicine that may be used. P2Y12 …

What are P2Y12 inhibitors? P2Y12 inhibitors are antiplatelet medications that work by blocking the P2Y12 receptor on platelet surfaces. P2Y12 inhibitors are used to stop thrombotic events in a range …

Jul 20, 2025 · P2Y12 is a protein located on the outer surface of platelets, which are small cell fragments circulating in the blood. These receptors are a subtype of P2Y receptors and are part of the body’s …

The P2Y12 receptor is a Gi-coupled ADP receptor first described in blood platelets where it plays a central role in the complex processes of activation and aggregation.

Feb 17, 2011 · P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries.